Relationship between β-Thalassemia minor and Helicobacter pylori infection

Authors

  • Ahmad Tamaddoni Non-Communicable Pediatric Diseases Research Center, Babol University of Medical Sciences, Babol, Iran
  • Ali Bijani Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
  • Amin Vahedi Student Research Committee, Babol University of Medical Sciences, Babol, Iran
  • Javad Shokri-Shirvani Department of Internal Medicine, Rohani Hospital, Babol University of Medical Sciences, Babol, Iran
  • Mohammad Zamani Student Research Committee, Babol University of Medical Sciences, Babol, Iran
  • Mojgan Bagherzade Department of Immunology, Babol University of Medical Sciences, Babol, Iran
Abstract:

Background: Until now, no study has been reported investigating the association between β-thalassemia minor and Helicobacter pylori (H. pylori) infection. This study was designed to compare H. pylori infection rate between β-thalassemia minor patients and healthy controls. Methods: A number of 100 β-thalassemia minor patients (50 males, 50 females) and 100 gender-matched healthy controls were prospectively recruited in this study in a period of 3 months. The study population consisted of the people who referred to a health center in Babol, North of Iran, for premarital counseling. H. pylori status was assessed by measuring the anti-H. pylori IgG antibodies using enzyme-linked immunosorbent assay. Demographic information and informed consent were collected from all participants. Results: The overall H. pylori infection rate was 43%. The infection was significantly more prevalent in thalassemia patients (53%) than in the controls (33%) in both univariate (OR=2.29, 95% CI: 1.3-4.06) and multivariable analyses (OR=2.05, 95% CI: 1.12-3.76). Age was the only significant factor which was positively correlated with the infection in β-thalassemia minor cases (OR=1.11, 95% CI: 1.02-1.2). Gender, blood groups, residency, and education level were not related to the infection. Conclusions: According to the results, it can be concluded that β-thalassemia minor patients are possibly more susceptible to H. pylori infection than healthy people. Further studies are needed to discover more about the exact mechanisms of increased susceptibility to H. pylori infection in β-thalassemia minor patients

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Journal title

volume 9  issue None

pages  54- 59

publication date 2018-01

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